Hemoglobin, rheumatoid factor, lipemia ,paraprotein(IGM) are known to interfere with this methodology. Digoxin-like immunoreactive factors (DLIF) or substances (DLIS) have been identified in blood from patients in renal failure, liver failure, newborns, and pregnant women in the third trimester. Studies have established that the presence of DLIF or DLIS in a sample can result in a false elevation of digoxin when assayed by commercially available immunoassays. 8, 9 In very rare cases, patient samples may contain a particle aggulutinating protein which may produce low results with this assay. |
